Packing early for Guatemala

One more week until I depart to Antigua Guatemala! Glad I started packing early. I opted for a large wheeled duffel bag. I didn't feel I would use a backpack that often, so I opted for this instead. But with all of my computer hardware and toiletries, it doesn't leave room or enough poundage for many clothes. 50# pounds of stuff is not much. I have to chose wisely on what to bring! I'll be there during all seasons, so I have to have warm clothes as well as summer stuff too.